Crystal structure of a Manα(1-2)Man specific lectin from Bowringia milbraedii
نویسنده
چکیده
Lectins are proteins of non-immune origin that specifically recognize carbohydrate structures. They are widespread in all kingdoms of life and mediate a variety of biological processes such as viral, bacterial and parasitic infections, growth and differentiation or cancer metastasis [1]. Plant lectins [2], especially those purified from the leguminous family [3], are among the best studied group of carbohydrate binding proteins. Legume lectins have for decades been a paradigm for proteincarbohydrate recognition because of their wide range of specificities for monosaccharides as well as for complex carbohydrates [4].
منابع مشابه
How a plant lectin recognizes high mannose oligosaccharides.
The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Manalpha(1-2)Manalpha(...
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